Jared Wright is an impressive high school student who has created a command line interface to Reddit.
AlienFeed is a simple, but effective, way of interacting with Reddit and takes advantage of Python's ability to open items in your web browser for you. It comes with a man page (unlike some Python CLIs) and a custom set of bash completions.
To try it out:
pip install alienfeed.
Here is screenshot to whet your appetite: