Eric Bailey’s take on CSS is certainly counter to the direction most are headed:

Human-friendly CSS is an interface that prioritizes people. It allows someone using your website or web app to easily make modifications to get what they need. This is huge because we can’t know who the person is, or what circumstances they’re experiencing.

Humans reading/modifying your CSS may seem like an edge case, but it’s more common than you think:

Stylus on the Chrome Web Store has more than half a million users. Stylish has over three million. That’s a lot of people modifying the web to get what they want.

He goes on to point out that even if it weren’t that many people, it’s still worth considering for other reasons. Lots to ponder.